Diagnosing and monitoring an inflammatory gastrointestinal disease may soon become less invasive and more accurate, thanks to the pioneering research and commitment to patient health of three University of Utah physicians. Gerald Gleich, Kristin Leiferman and Kathryn Peterson have developed away to identify inflammation that occurs in eosinophil-related disorders such as eosinophilic esophagitis (EoE), a chronic and painful inflammatory condition of the esophagus that can strike at any age. EoE affects roughly 300,000 people in the United States alone.
Gleich, professor of internal medicine and dermatology at the U, discovered that eosinophils contain a major basic protein, a toxic substance that damages tissue where it is deposited after eosinophils release it, causing inflammation. He and his team also identified a compound that can bind to major basic protein.
“If a patient swallows this proprietary imaging agent, X-ray-like images will reveal inflamed tissue in which eosinophil major basic protein is deposited,” said Gleich. In addition to confirming that EoE is causing the pain, the imaging also will identify precisely where the affected tissue is in the esophagus and how much of the esophagus is affected.
NexEos is a subsidiary of pharmaceutical holding company NeXeption. Steve Tullman, NeXeption’s founder and managing member, has followed Gleich’s work for 20 years. “Jerry has dedicated much of his career to understanding and ameliorating eosinophil-related disease,” said Tullman. “He has found champions in both TVC and me, and we are excited to help carry forth his vision.”
“Bringing diagnostics and therapeutics to market is a relay race, and we rely on trusted partners to whom we can pass the baton,” said Keith Marmer, TVC’s executive director. “NexEos has put in place a strong management team to navigate the regulatory milestones, develop a solid market strategy and secure investment.”
NexEos has raised private funding and is applying for Small Business Innovation Research grants through the NIH. Theresa Mansi, a 30-year veteran of the pharmaceutical industry who has been named CEO, views EoE as just the beginning for NexEos. “We can identify eosinophil-related inflammation in the esophagus of patients with EoE,” said Mansi. “This new diagnostic also has the potential to identify and diagnose other diseases in which eosinophils are the drivers of inflammationsuch as eosinophilic asthma and eosinophilic gastroenteritis. We are dedicated to helping improve the quality of life for patients suffering with these chronic conditions. That is what motivates us every day.”
About the Center for Technology & Venture Commercialization
The Center for Technology & Venture Commercialization is dedicated to helping the University of Utah’s faculty inventors bring their innovations to market. TVC is responsible for all aspects of invention management, patent prosecution, licensing, startup formation and support, equity management and early-stage funding. The center’s mission is to generate economic returns for the university and the state of Utah, expand the university’s reputation for innovation, and positively impact society. In 2017 the University of Utah was ranked as the number-one university for technology commercialization in the country by the Milken Institute. TVC is proud to help foster this spirit of discovery.
About NexEos Diagnostics, Inc.
NexEos Diagnostics, Inc. is a privately held medical diagnostics company dedicated to improving the diagnosis, lifelong management, and treatment of patients living with chronic, eosinophil-related inflammatory diseases. Through the licensing, development and commercialization of novel technologies, NexEos Diagnostics, Inc. is focused on bringing new tools to market that address the unmet needs of patients suffering with eosinophil-related diseases including eosinophilic esophagitis (EoE) and eosinophilic asthma. NexEos’ lead program is a novel, non-invasive imaging agent for the diagnosis, treatment monitoring, and management of eosinophilic esophagitis (EoE), which will help patients to maintain quality of life and halt their disease progression. For more information go to www.nexeosdx.com.